AICAR, short for 5-Aminoimidazole-4-carboxamide ribonucleotide, is a powerful AMP-activated protein kinase (AMPK) activator used extensively in metabolic and endurance research. QRP Nutrition offers AICAR QRP Nutrition 50mg in high-purity, research-grade form for professionals and laboratories focused on exploring its effects on energy metabolism, fat oxidation, and cellular adaptation.
What Is AICAR?
AICAR is an analog of adenosine monophosphate (AMP) and functions by mimicking AMP in the body, directly activating AMPK, the “master switch” of cellular energy homeostasis. AMPK plays a critical role in:
- Stimulating glucose uptake
- Increasing mitochondrial activity
- Enhancing fatty acid oxidation
- Inhibiting anabolic pathways when energy is low
Originally researched for its potential in treating metabolic disorders and cardiac ischemia, AICAR has drawn attention for its performance-enhancing effects in animal studies.
Key Research Applications
1. Endurance Enhancement
- AICAR has been shown in rodent models to increase endurance by over 40%, even in sedentary animals, through mitochondrial biogenesis.
2. Fat Metabolism
- Promotes lipid oxidation, reducing fat accumulation in the liver and skeletal muscle.
3. Insulin Sensitivity
- Improves glucose transport and insulin response, making it relevant for diabetes-related research.
4. Muscle Preservation
- Encourages energy-efficient metabolism, reducing muscle breakdown during caloric deficit or inactivity.
QRP Nutrition AICAR 50mg: Features & Quality
- Purity > 99%, verified by third-party lab testing (HPLC and MS reports available)
- Lyophilized powder for flexible reconstitution (researchers may mix with bacteriostatic water or other sterile solvents)
- GMP-Certified Manufacturing: Ensures consistency and sterility in each vial
- Batch-traceable with Certificates of Analysis upon request
⚖️ Suggested Research Handling
⚠️ For research use only. Not for human consumption.
- Reconstitution: Dissolve 50mg in 2–5mL of sterile solution for desired concentration (e.g., 10mg/mL).
- Typical Lab Dose: Animal studies have used doses ranging from 10 to 50mg per kg of body weight, depending on research objective.
- Duration: Research protocols vary from 1–4 weeks, with some endurance-focused trials extending to 6 weeks.
AICAR vs. Other Metabolic Compounds
| Compound | Target Pathway | Main Focus | Research Use |
|---|---|---|---|
| AICAR | AMPK Activator | Mitochondria & Fat Oxidation | Metabolic adaptation |
| Cardarine | PPARδ Agonist | Fat burning & Endurance | Energy metabolism |
| Metformin | AMPK via LKB1 | Glucose control | Anti-aging, diabetes |
| MK-677 | GH Secretagogue | Muscle growth | Anabolism, recovery |
AICAR is unique in simulating exercise-like metabolic effects even without physical activity, which has made it a subject of interest for anti-doping regulators as well as longevity and performance researchers.
⚠️ Safety and Considerations
- Short-Term Safety: Generally well-tolerated in controlled research. Some subjects show fatigue, hypoglycemia, or gastrointestinal sensitivity at higher doses.
- Long-Term Data: Limited in humans; rodent data supports its role in improving energy balance and protecting metabolic health.
- Not approved for human use: Must be used in controlled environments for research purposes only.
Why Choose QRP Nutrition’s AICAR?
✅ Lab-Grade Reliability
✅ Batch Consistency with COA Documentation
✅ Worldwide Shipping to Research Facilities
✅ Responsive Support Team for Scientific Inquiries
Conclusion
QRP Nutrition’s AICAR 50mg formulation delivers high-purity AMPK activation potential for researchers studying energy metabolism, endurance, and fat oxidation. Whether you’re investigating therapeutic options for metabolic disorders or exploring performance applications in preclinical models, AICAR remains a valuable compound in the research toolbox.
This content is intended for licensed researchers and laboratories. AICAR is not intended for medical, human, or veterinary use.
Leave a Reply